Preliminary results on the uptake and biochemical response to water-exposure of Tamiflu® (oseltamivir phosphate) in two marine bivalves.
Identifieur interne : 000866 ( Main/Exploration ); précédent : 000865; suivant : 000867Preliminary results on the uptake and biochemical response to water-exposure of Tamiflu® (oseltamivir phosphate) in two marine bivalves.
Auteurs : Sara Dallarés [Espagne] ; Nicola Montemurro [Espagne] ; Sandra Pérez [Espagne] ; Neus Rodríguez-Sanchez [Royaume-Uni] ; Montserrat Solé [Espagne]Source :
- Journal of toxicology and environmental health. Part A [ 1528-7394 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- enzymologie : Bivalvia, Mytilus.
- métabolisme : Antioxydants, Bivalvia, Esterases, Marqueurs biologiques, Mytilus.
- Animaux, Biotransformation, Hémolymphe, Peroxydation lipidique, Spécificité d'espèce, Stress oxydatif.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Antioxidants, Biomarkers, Esterases.
- chemistry : Hemolymph.
- enzymology : Bivalvia, Mytilus.
- metabolism : Bivalvia, Mytilus.
- Animals, Bioaccumulation, Biotransformation, Lipid Peroxidation, Oxidative Stress, Species Specificity.
Abstract
Tamiflu® (oseltamivir phosphate, OST) is an antiviral drug used for the pandemic treatment of avian influenza but few data are available regarding its toxicity. It should be noted that acute adverse responses are not likely to occur due to low environmental presence of this drug. Nonetheless, water concentration levels of this compound may reach the µg/L range under influenza episodes. Bivalves are reliable sentinels of chemical exposure due to their low metabolism; however, biotransformation of drugs does occur in these aquatic invertebrates. Two species of bivalves, namely mussels Mytilus galloprovincialis and clams Ruditapes philippinarum, were exposed for 48 h to 100 µg/L OST. Hemolymph from control and treated bivalves was withdrawn and the presence of OST and its metabolite oseltamivir carboxylate (OST-C) determined by LC-MS/MS. Gills and digestive gland were excised from control and exposed bivalves and carboxylesterase (CE) activities measured using different substrates. In addition, antioxidant defences and lipid peroxidation levels were determined. Higher metabolism of OST seemed to occur in mussels, since both OST and OST-C were found in hemolymph, whereas in clams only the parent compound was detected. In contrast, biomarker responses were more evident in exposed clams which indicate that this species may be considered as more sensitive to OST exposure. CE-related activities successfully reflected OST exposure, with substrates 1-naphthyl acetate (1NA) and 1-naphthyl butyrate (1NB) displaying the highest sensitivity in the two bivalve species. Data thus indicate the usefulness of CE-related activities as biomarkers for OST exposure in bivalves.
DOI: 10.1080/15287394.2018.1562393
PubMed: 30669952
Affiliations:
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Le document en format XML
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Sara" uniqKey="Dallares S" first="Sara" last="Dallarés">Sara Dallarés</name><affiliation wicri:level="1"><nlm:affiliation>a Institute of Marine Sciences (ICM-CSIC) , Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>a Institute of Marine Sciences (ICM-CSIC) , Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author><author><name sortKey="Montemurro, Nicola" sort="Montemurro, Nicola" uniqKey="Montemurro N" first="Nicola" last="Montemurro">Nicola Montemurro</name><affiliation wicri:level="1"><nlm:affiliation>b Institute for Environmental Assessment and Water Research (IDAEA-CSIC) , Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>b Institute for Environmental Assessment and Water Research (IDAEA-CSIC) , Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author><author><name sortKey="Perez, Sandra" sort="Perez, Sandra" uniqKey="Perez S" first="Sandra" last="Pérez">Sandra Pérez</name><affiliation wicri:level="1"><nlm:affiliation>b Institute for Environmental Assessment and Water Research (IDAEA-CSIC) , Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>b Institute for Environmental Assessment and Water Research (IDAEA-CSIC) , Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Sanchez, Neus" sort="Rodriguez Sanchez, Neus" uniqKey="Rodriguez Sanchez N" first="Neus" last="Rodríguez-Sanchez">Neus Rodríguez-Sanchez</name><affiliation wicri:level="1"><nlm:affiliation>c Chemicals Regulation Directorate , Bootle , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>c Chemicals Regulation Directorate , Bootle </wicri:regionArea><wicri:noRegion>Bootle </wicri:noRegion></affiliation></author><author><name sortKey="Sole, Montserrat" sort="Sole, Montserrat" uniqKey="Sole M" first="Montserrat" last="Solé">Montserrat Solé</name><affiliation wicri:level="1"><nlm:affiliation>a Institute of Marine Sciences (ICM-CSIC) , Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>a Institute of Marine Sciences (ICM-CSIC) , Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of toxicology and environmental health. Part A</title><idno type="ISSN">1528-7394</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antioxidants (metabolism)</term><term>Bioaccumulation</term><term>Biomarkers (metabolism)</term><term>Biotransformation</term><term>Bivalvia (enzymology)</term><term>Bivalvia (metabolism)</term><term>Esterases (metabolism)</term><term>Hemolymph (chemistry)</term><term>Lipid Peroxidation</term><term>Mytilus (enzymology)</term><term>Mytilus (metabolism)</term><term>Oxidative Stress</term><term>Species Specificity</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antioxydants (métabolisme)</term><term>Biotransformation</term><term>Bivalvia (enzymologie)</term><term>Bivalvia (métabolisme)</term><term>Esterases (métabolisme)</term><term>Hémolymphe ()</term><term>Marqueurs biologiques (métabolisme)</term><term>Mytilus (enzymologie)</term><term>Mytilus (métabolisme)</term><term>Peroxydation lipidique</term><term>Spécificité d'espèce</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term><term>Biomarkers</term><term>Esterases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hemolymph</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Bivalvia</term><term>Mytilus</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Bivalvia</term><term>Mytilus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bivalvia</term><term>Mytilus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antioxydants</term><term>Bivalvia</term><term>Esterases</term><term>Marqueurs biologiques</term><term>Mytilus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bioaccumulation</term><term>Biotransformation</term><term>Lipid Peroxidation</term><term>Oxidative Stress</term><term>Species Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Biotransformation</term><term>Hémolymphe</term><term>Peroxydation lipidique</term><term>Spécificité d'espèce</term><term>Stress oxydatif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tamiflu® (oseltamivir phosphate, OST) is an antiviral drug used for the pandemic treatment of avian influenza but few data are available regarding its toxicity. It should be noted that acute adverse responses are not likely to occur due to low environmental presence of this drug. Nonetheless, water concentration levels of this compound may reach the µg/L range under influenza episodes. Bivalves are reliable sentinels of chemical exposure due to their low metabolism; however, biotransformation of drugs does occur in these aquatic invertebrates. Two species of bivalves, namely mussels Mytilus galloprovincialis and clams Ruditapes philippinarum, were exposed for 48 h to 100 µg/L OST. Hemolymph from control and treated bivalves was withdrawn and the presence of OST and its metabolite oseltamivir carboxylate (OST-C) determined by LC-MS/MS. Gills and digestive gland were excised from control and exposed bivalves and carboxylesterase (CE) activities measured using different substrates. In addition, antioxidant defences and lipid peroxidation levels were determined. Higher metabolism of OST seemed to occur in mussels, since both OST and OST-C were found in hemolymph, whereas in clams only the parent compound was detected. In contrast, biomarker responses were more evident in exposed clams which indicate that this species may be considered as more sensitive to OST exposure. CE-related activities successfully reflected OST exposure, with substrates 1-naphthyl acetate (1NA) and 1-naphthyl butyrate (1NB) displaying the highest sensitivity in the two bivalve species. Data thus indicate the usefulness of CE-related activities as biomarkers for OST exposure in bivalves.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Royaume-Uni</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Dallares, Sara" sort="Dallares, Sara" uniqKey="Dallares S" first="Sara" last="Dallarés">Sara Dallarés</name></noRegion><name sortKey="Montemurro, Nicola" sort="Montemurro, Nicola" uniqKey="Montemurro N" first="Nicola" last="Montemurro">Nicola Montemurro</name><name sortKey="Perez, Sandra" sort="Perez, Sandra" uniqKey="Perez S" first="Sandra" last="Pérez">Sandra Pérez</name><name sortKey="Sole, Montserrat" sort="Sole, Montserrat" uniqKey="Sole M" first="Montserrat" last="Solé">Montserrat Solé</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Rodriguez Sanchez, Neus" sort="Rodriguez Sanchez, Neus" uniqKey="Rodriguez Sanchez N" first="Neus" last="Rodríguez-Sanchez">Neus Rodríguez-Sanchez</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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